منابع مشابه
Snake Venom Toxins
A toxin, designated Fvrr has been isolated from the venom of the green mamba Dendroaspis angusticeps by ion exchange chromatography on Amberlite CG-50 and gel filtration on Sephadex G-50. . Toxin FvII consists of 61 amino acid residues, is devoid of phenylalanine and tryptophan, and is cross-linked by four intramolecular disulfide bridges. Immunochemically, toxin FvII is completely distinct fro...
متن کاملComputational Studies of Snake Venom Toxins
Most snake venom toxins are proteins, and participate to envenomation through a diverse array of bioactivities, such as bleeding, inflammation, and pain, cytotoxic, cardiotoxic or neurotoxic effects. The venom of a single snake species contains hundreds of toxins, and the venoms of the 725 species of venomous snakes represent a large pool of potentially bioactive proteins. Despite considerable ...
متن کاملTargeting Metastasis with Snake Toxins: Molecular Mechanisms
Metastasis involves the migration of cancer cells from a primary tumor to invade and establish secondary tumors in distant organs, and it is the main cause for cancer-related deaths. Currently, the conventional cytostatic drugs target the proliferation of malignant cells, being ineffective in metastatic disease. This highlights the need to find new anti-metastatic drugs. Toxins isolated from sn...
متن کاملVenom Down Under: Dynamic Evolution of Australian Elapid Snake Toxins
Despite the unparalleled diversity of venomous snakes in Australia, research has concentrated on a handful of medically significant species and even of these very few toxins have been fully sequenced. In this study, venom gland transcriptomes were sequenced from eleven species of small Australian elapid snakes, from eleven genera, spanning a broad phylogenetic range. The particularly large numb...
متن کاملSnake venom toxins. The amino acid sequences of toxins b and d from Naja melanoleuca venom.
Two toxins have been isolated from the venom of the Forest cobra (Naja melanoleuca) and their amino acid sequences elucidated. Toxin b, a 71 amino acid residue molecule, is devoid of methionine and resembles toxin (x from Naja nivea venom both immunochemically and in amino acid sequence. Toxin d consists of 61 amino acid residues with alanine, phenylalanine, and leucine totally absent. Toxin d ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.16.9362